PCT、BNP、D-D 二聚体及 APACHEⅡ评分预测脓毒症患者预后的研究

摘要

Objective To evaluate the value of PCT, BNP, D-D dimmer and APACHEⅡ system score in predicting the prognosis of sepsis patients. Methods 66 sepsis patients were selected in the study, and their values of PCT, BNP, D-D dimmer and APACHEⅡsystem score were measured on Day 1, 3, and 7 after intensive care medicine unit admission. The area under the receiver operating characteristic curve was evaluated by ROC curve. Re-sults The values of PCT, BNP, and APACHEⅡsystem score were significantly higher the survival group than in the death group (P < 0. 05). The area under the receiver operating characteristic curve for predicting the 28 day mortality of sepsis patients were all more than 0. 7. However, there was no significant difference in the D-D dimmer between the two groups (P > 0. 05). Conclusion The high level of PCT, BNP, and APACHEⅡsystem score can predict poor prognosis in sepsis patients.%目的：探讨 PCT、BNP、D-D 二聚体水平及 APACHEⅡ评分预测脓毒血症患者预后的作用。方法比较分析死亡组与生存组脓毒症患者第1、3、7天检测 PCT、BNP、D-D 二聚体水平及 APACHEⅡ评分，采用受试者工作曲线(ROC)评估上述指标与预后的关系。结果与生存组患者相比，死亡组住院第1、3、7天PCT、BNP 及 APACHEⅡ评分显著增高(P <0．05)，死亡组和生存组的 D-D 二聚体水平差异无统计学意义(P>0．05)。 PCT、BNP、APACHEⅡ评分住院第1、3、7天 ROC 曲线下面积(AUC)均>70%。结论高 PCT、BNP及 APACHEⅡ评分可作为脓毒症患者不良预后的指标。