目的：观察帕洛诺司琼和托烷司琼两种止吐药预防化疗所致恶心、呕吐的临床疗效和安全性。方法74例患者随机分为两组，观察组37例使用帕洛诺司琼，对照组37例采用托烷司琼，比较两组预防急性呕吐(化疗后24 h内)和迟发性呕吐(化疗后2-5天内)的有效率和安全性。结果预防急性呕吐帕洛诺司琼组有效率为89．2%，托烷司琼组有效率为83．8%，两组疗效差异无统计学意义( P>0．05)；预防迟发性呕吐帕洛诺司琼组完全缓解率为64．9%，托烷司琼组为40．5%，两组差异有统计学意义( P<0．05)。帕洛诺司琼主要不良反应为头痛、便秘。结论帕洛诺司琼预防急性呕吐的有效率与托烷司琼相当，预防迟发性呕吐的有效率优于托烷司琼，且不良反应轻微。%Objective To observe the efficacy and safety of palonosetron and tropisetron to prevent nausea and emesis caused by chemotherapy for cancer. Methods 74 patients were randomly divided into two groups. The group A (n=37) was given palonosetron, and the group B (n=37) was given tropisetron before chemotherapy. The efficiency and safety to prevent acute emesis (during the 24 hours after chemotherapy) and delayed emesis (2-5 days post-chemotherapy) were observed. Results The effective rate to prevent acute emesis ( during the 24 hours after chemotherapy) were 89. 2% for palonosetron and 83. 8% for tropisetron respectively ( P>0. 05 ) . The complete re-sponse rate of delayed emesis was 64. 9% for palonosetron, and 40. 5% for tropisetron (P<0. 05). The adverse re-actions of palonosetron were headache and constipation. Conclusion The effect of palonosetron to prevent acute em-esis is similar with tropisetron, but it is superior to tropisetron for preventing delayed emesis with fewer adverse reac-tions.
展开▼
