目的 孟鲁司特钠对毛细支气管炎患儿IL-17和IL-23表达的影响.方法 收集2013年5月~2015年5月我院儿科治疗的毛细支气管炎患儿80例,使用随机数字法分为常规治疗对照组和孟鲁司特钠治疗观察组.ELISA法检测IL-17和IL-23表达,比较两组的临床疗效.结果 两组治疗前IL-17和IL-23表达无显著性差异(P>0.05),两组治疗后IL-17和IL-23表达均显著减低(P<0.01),但治疗后观察组IL-17和IL-23表达显著低于对照组(P<0.05).观察组临床治疗有效率为92.5%,显著高于对照组的77.5%(P<0.05).结论 孟鲁司特钠可以减低毛细支气管炎患儿IL-17和IL-23因子表达,,临床疗效显著,治疗安全,具有一定的临床应用价值.%Objective To detect the effect of montelukast on IL-17 and IL-23 expression in children with bronchiolitis. Methods A total of 80 children with bronchiolitis were enrolled from our hospital, and they were ran-domly divided into the control group (n=40) and the montelukast observation group (n=40). The IL-17 and IL-23 expressions were detected by ELISA analysis. The clinical effect and adverse reactions were compared. Results Be-fore treatment, there was no significant difference in IL-17 and IL-23 expression between the two groups(P>0. 05). After the treatment, the expressions of IL-17 and IL-23 were lower in the observation group than in the control group (P<0. 05). The clinical effective rate was 92. 5% in the observation group, which was significantly higher than 77. 5% in the control group (P<0. 05). Conclusion Montelukast could decrease IL-17 and IL-23 expression in chil-dren with bronchiolitis, with significantly clinical efficacy and safety.
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