目的：探讨阿司匹林早期干预对于ARDS患者长期预后的影响研究。方法连续性纳入60例ARDS患者,随机分为治疗组和对照组。详细记录所有入选患者的年龄,性别,病史,氧合等基本情况。计算APACHE II评分和SOFA评分,并记录ICU住院时间、死亡率等。观察阿司匹林干预后对于患者临床预后的影响。结果在死亡率和平均ICU住院时间方面,可见治疗组均优于对照组,但未见明显统计学差异( P>0．05)。阿司匹林治疗与ARDS患者死亡(r=-0．483,P=0．03)和ICU平均住院时间(r=-0．312,P=0．29)存在负相关。通过多变量 Logistic 回归分析,可见阿司匹林治疗可以使 ARDS 死亡风险降低25%( P =0．002)。通过cox回归分析显示阿司匹林治疗可使ARDS第14天死亡率降低7%(P=0．03)。结论早期阿司匹林抗血小板治疗可能有助于ARDS患者的临床预后。%Objective To evaluate the influence of aspirin administration on clinical prognosis of patients with ARDS. Methods 60 patients with ARDS were enrolled in this study and randomly divided into two groups:the treatment group and the control group. Their age, sexuality, history of illness and oxygenation were recorded. The scores of APACHE Ⅱ and SOFA were calculated. Their mortality and stay in ICU were recorded, and the influence of aspirin administration on clinical prognosis were evaluated. Results The mortality and the average stay in ICU were lower in the treatment group than in the control group ( P >0. 05 ) . Correlation analysis showed that aspirin treatment was negatively associated with death (r=-0. 483, P=0. 03) and average stay in ICU (r= -0. 312, P=0. 29) of ARDS patients. Multivariable logistic analysis showed the aspirin treatment might decrease 25% of mortali-ty. Cox analysis showed aspirin might reduce 7% of mortality in the 14th day of ARDS patients. Conclusion Early aspirin treatment can improve the clinical prognosis of patients with ARDS.
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