目的 探讨术前血清中可溶性RANKL/OPG水平与胸腺瘤术后复发的相关性,从而评价其在预测胸腺瘤术后复发中的价值.方法 采用酶联免疫吸附试验检测行正中切口手术的115例胸腺瘤患者术前血清OPG、RANKL水平,随访28(12-72)个月后25例出现了复发.结果 ①复发组的血清RANKL、RANKL/OPG水平显著高于未复发组;②最佳截断点上血清RANKL/OPG诊断胸腺瘤术后复发的敏感性、特异性和正确率分别为90.1%、85.4%、87.7%.结论 术前血清可溶性RANKL/OPG水平与胸腺瘤术后复发相关,它可作为术前评价胸腺瘤远期复发的辅助临床指标,指导手术方式的选择和术后辅助治疗.%Objective To explore the relationship between serum level of RANKL/OPG and postoperative recurrence of thymoma, thereby to evaluate it in predicating prognosis of thymoma. Methods 115 thymoma patients receiving median incision operation were completed follow-up. Enzyme-linked immunosorbent assay was used to deter-mine the serum level of OPG and RANKL. Results The level of serum RANKL/OPG was obviously higher in the re-currence group than in the non-recurrence group. According to Youden index of ROC curve, the best cut-off points of serum RANKL/OPG for predicating recurrence of thymoma was emerged. The diagnostic sensitivity, specificity and accuracy of the cut-off point were 90. 1%, 85. 4% and 87. 7% respectively. Conclusion The serum level of RANKL/OPG is associated with the recurrence of thymoma. It can be used to evaluate long-term prognosis of thy-moma as a secondary clinical parameter, which can guide the choose of surgery program and adjuvant therapy after surgery.
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