血清CEA联合胸腔积液CEA对恶性胸腔积液的诊断意义

摘要

目的 探讨联合检测血清癌胚抗原(CEA)、胸腔积液CEA对恶性胸腔积液诊断的临床意义.方法 收集了2010年10月至2015年1月,安徽省胸科医院和安徽医科大学第一附属医院349例胸腔积液患者为研究对象,其中有155例肺癌伴胸膜转移患者(简称"恶性胸腔积液"),194例胸腔积液为良性病变包括结核性胸膜炎、肺炎旁胸腔积液和漏出性胸腔积液患者(简称"良性胸腔积液").抽取患者外周血及胸腔积液,并采用电化学发光免疫分析法进行CEA定量分析.结果 恶性胸腔积液患者血清CEA和胸腔积液CEA均显著高于良性胸腔积液患者,ROC结果提示血清CEA联合胸腔积液CEA对于恶性胸腔积液的诊断敏感性提高至0.858,且AUC值升至0.946,具有显著性差异.结论 血清CEA联合胸腔积液CEA可以显著提高对恶性胸腔积液的诊断意义.%Objective To investigate the clinical significance of combined detection of serum carcinoembry-onic antigen ( CEA) and pleural effusion CEA in diagnosis of malignant pleural effusion. Methods From January 2010 to January 2015, 349 inpatients with pleural effusion in the Anhui Chest Hospital and the First Affiliated Hospi-tal of Anhui Medical University were involved in present study, including 155 cases of lung cancer complicated with pleural metastasis ( referred to as"malignant pleural effusion", the same below) , 194 cases of benign diseases inclu-ding tuberculosis pleurisy, parapneumonic pleural effusion and leakage of pleural effusion ( referred to as "benign pleural effusion", the same below) . The peripheral blood and pleural effusion were extracted, and CEA quantitative analysis was performed by using the method of electrochemical luminescence immunoassay. Results The serum CEA and pleural effusion CEA in malignant pleural effusion were significantly higher than those patients with benign pleural effusion. Receiver operating characteristic curve ( ROC) results suggested the combination of serum CEA and pleural effusion CEA could obviously increase the sensitivity to 0. 858 and AUC to 0. 946. Conclusion Serum CEA com-bined with pleural effusion CEA can significantly improve the diagnostic value of malignant pleural effusion.