目的 分析并探讨孟鲁司特钠预防小儿哮喘急性发作的临床效果.方法 选取小儿哮喘患儿200例,随机分为观察组与对照组,各100例.对照组治疗出院后不予以预防性治疗,治疗组治疗出院后给予孟鲁司特钠预防性治疗,观察1年后患者免疫指标,以及期间发作的次数.观察首次复发时临床效果.结果治疗后观察组症状评分明显低于对照组(P<0.05).观察组PEFR、FEV1以及急性加重率明显优于对照组(P<0.05).观察组平均发作次数低于对照组(P<0.05),且两组免疫指标有显著差异(P<0.05)结论 孟鲁司特钠预防小儿哮喘急性发作的临床效果显著,复发率低.%Objective To analyze and discuss the clinical effect of montelukast in prevention of acute attack of children with asthma. Methods 200 pediatric asthma children were randomly divided into the observation group and the control group, 100 cases in each group. The control group wasn't given preventive treatment after discharge, and the observation group was given montelukast preventive treatment. Their immune indexes and the times of attack during 1 year were observed, and the clinical effect of first recurrence was also observed. Results Symptom scores after treatment were obviously lower in the observation group than in the control group (P<0. 05). PEFR, FEV1 and acute exacerbation rate were obviously better in the observation group than in the control group (P<0. 05). The av-erage onset times was lower in the observation group than in the control group (P<0. 05), and the immune indexes had significant difference (P<0. 05). Conclusion Montelukast has significant clinical effect and it can reduce the times of acute attack in prevention of children with asthma.
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