目的：探讨经支气管镜局部药物注射治疗耐多药肺结核的临床疗效以及患者免疫功能的变化。方法选取2年内耐多药肺结核患者74例，平均分为两组，研究组选择化疗结合纤支镜局部注射，对照组选择单纯化疗。结果治疗9个月后研究组痰菌转阴率与病灶吸收率显著高于对照组(P<0．05)，各项免疫功能指标改善程度均明显优于对照组(P<0．05)，不良反应发生率比较差异无统计学意义(P>0．05)。结论经纤支镜局部药物注射能够有效改善耐多药肺结核患者的临床治疗有效性，提高痰结核分枝杆菌转阴率并促进病灶吸收，改善患者免疫功能。%Objective To observe the clinical efficacy and the change of immune function of bronchoscopy local injection as adjuvant treatment for multi-drug resistant tuberculosis. Methods 74 multi-drug resistant tubercu-losis patients were divided into two groups. The study group was given bronchoscopy local injection combined with chemotherapy, and the control group was given chemotherapy only. Results 9 months after treatment,? the negative conversion rate and focus absorption rate were significantly higher in the study group than in the control group ( P<0. 05 ) , and the improvement of immune function indexes was more pronounced in the study group than in the control group (P<0. 05). There was no significant difference in adverse reactions between the two groups. Conclusion Bronchoscopy local injection can effectively improve the clinical treatment of multi-drug resistant tuberculosis pa-tients, increase the negative conversion rate and focus absorption rate, and improve their immune system function.
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