深部热疗对老年非小细胞肺癌患者临床多项指标的研究

摘要

Objective To investigate the effect of bronchial artery infusion chemotherapy combined with hyper-thermia on blood coagulation function and serum tumor markers in elderly patients with non-small cell lung cancer, and to analyze the possible mechanism of improving short-term curative effect. Methods 124 elderly patients with non-small cell lung cancer patients were randomly divided into the observation group and the control group with 62 cases in each group. The control group was given bronchial artery infusion chemotherapy, and the observation group was treated with bronchial artery infusion chemotherapy combined with hyperthermia. After 2 courses of treatment, their blood coag-ulation and tumor markers, and clinical efficacy were compared. Results Their prothrombin time (PT), activated partial thromboplastin time ( APTT) , fibrinogen ( FIB) , and D-dimer ( D-D) were significantly lower in the observa-tion group than in the control group (P<0. 05, P<0. 01). Their serum carcinoembryonic antigen (CEA), carbohy-drate antigen 125 (CA125), and cytokeratin 19 fragment antigen (CYFRA21-1) were significantly lower in the obser-vation group than in the control group (P<0. 05, P<0. 01). The clinical efficiency and the disease control rate were significantly higher in the observation group than in the control group (P<0. 05). There was no significant difference in gastrointestinal reactions, bone marrow depression, hair loss or liver function injury between the two groups ( P>0. 05). Conclusion Bronchial arterial infusion chemotherapy combined with deep hyperthermia is helpful to improve the short-term curative effect of elderly patients with non-small cell lung cancer, which may be related to improving blood coagulation function and reducing the content of serum tumor markers.%目的 探讨支气管动脉灌注化疗联合深部热疗对老年非小细胞肺癌患者凝血功能及血清肿瘤标志物的影响,分析其提高近期疗效的可能作用机制.方法 选择老年非小细胞肺癌患者124例为研究对象,采用随机数字表法分为观察组和对照组各62例,对照组采用支气管动脉灌注化疗,观察组采用支气管动脉灌注化疗联合深部热疗,治疗2个疗程后,比较两组凝血功能、肿瘤标志物、近期疗效等指标.结果 观察组患者凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)含量明显低于对照组(P<0.05,P<0.01);血清癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段抗原(CYFRA21-1)含量明显低于对照组(P<0.05,P<0.01);有效率、疾病控制率均明显高于对照组(P<0.05);两组消化道反应、骨髓抑制、脱发、肝功能损伤等比较无统计学意义(P>0.05).结论 支气管动脉灌注化疗联合深部热疗有助于提高老年非小细胞肺癌患者近期疗效,可能与改善患者凝血功能、降低血清肿瘤标志物含量有关.