体液免疫变化对哮喘-慢性阻塞性肺疾病重叠综合征肺功能的影响

摘要

目的 探讨体液免疫变化对哮喘-慢性阻塞性肺疾病重叠综合征肺功能的影响.方法 选择2015年1月至2016年12月本院收治的哮喘-慢性阻塞性肺疾病重叠综合征患者40例为观察组,同时选择同期正常体检者40例为正常组,对所有入组者其体液免疫功能进行检查,同时测定其肺功能,重点了解第一秒用力呼气容积(FEV1%)变化,并计算sIgA水平与FEV1相关性及IgM与FEV1相关性.结果 观察组IgM、IgG、IgA及sIgA水平均明显低于正常组(P<0.05),观察组FEV1小于正常组(P<0.05),FEV1/FVC水平低于正常组(P<0.05),哮喘-慢性阻塞性肺疾病重叠综合征机体sIgA水平及IgM与FEV1值呈正相关(r=0.8611和0.8421,P=0.000<0.05).结论 哮喘-慢性阻塞性肺疾病综合征患者,其机体免疫力降低,肺功能变差,且机体免疫能力与肺功能变化之间存在正相关性.%Objective To investigate the effect of humoral immune changes on lung function in patients with asth-ma-chronic obstructive pulmonary disease complicated syndrome. Methods 40 patients with asthma-chronic obstruc-tive pulmonary disease were enrolled in our hospital from January 2015 to December 2016,and 40 patients with nor-mal physical examination were selected as the normal group. The correlation between the level of sIgA and FEV1and the relationship between IgM and FEV1were calculated. The changes of FEV1% were performed. Results The lev-els of IgM,IgG,IgA and sIgA in the observation group were significantly lower than those in the normal group(P<0.05). The FEV1/ FVC level in the observation group was lower than that in the normal group. sIgA and IgM were positively correlated with FEV1(r=0.8611 and 0.8421, P<0.05). Conclusion Their body immunity decreases and lung function worsens,and the body immunity and lung function changes have positive correlation in patients with asthma -chronic obstructive pulmonary disease complicated syndrome.