重复经颅磁刺激治疗广泛性焦虑障碍对照研究

摘要

Objective To explore the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in the treatment of generalized anxiety disorder (GAD) .Methods Sixty GAD patients were ran‐domly assigned to two groups ,research received rTMS and took orally vitamin complex tablets ,and con‐trol group took orally buspirone and was plus pseudo‐rTMS for 4 weeks .Efficacies were assessed with Hamilton Anxiety Scale (HAMA) ,Self‐rating Anxiety Scale (SAS) and Pittsburgh Sleep Quality Index (PSQI) before and after treatment and adverse reactions recorded at any time .Results All scales scores of both groups at each time point lowered more significantly compared with pretreatment (P<0.01) ,there were no significant group differences in the corresponding period (P> 0.05) .Severe adverse reactions didn’t appeared during treatment in both groups .Conclusion The rTMS has an evident effect equivalent to buspirone ,higher safety and better compliance in GAD .%目的：探讨重复经颅磁刺激治疗广泛性焦虑障碍患者的疗效和安全性。方法将60例广泛性焦虑障碍患者随机分为两组，研究组予以重复经颅磁刺激，同时口服复合维生素片治疗，对照组口服丁螺环酮治疗，同时予以经颅磁假刺激，观察4周。于治疗前后采用汉密顿焦虑量表、焦虑自评量表、匹兹堡睡眠质量指数量表评定临床疗效，随时记录治疗过程中出现的不良反应。结果治疗各时点两组各量表评分均较治疗前显著下降（P＜0.01），同期两组间评分比较差异均无显著性（ P＞0.05）；治疗过程中两组均未出现严重不良反应。结论重复经颅磁刺激治疗广泛性焦虑障碍疗效显著，与丁螺环酮相当，治疗安全性高，依从性好。