目的：探讨帕罗西汀联合认知行为疗法治疗强迫症的临床疗效及安全性。方法将90例强迫症患者随机分为两组，均予以帕罗西汀治疗，研究组在此基础上联合认知行为治疗，观察12周。于治疗前和治疗各时段采用耶鲁‐布朗强迫量表、副反应量表评定临床疗效及不良反应。结果治疗4周末起两组耶鲁‐布朗强迫量表评分均较治疗前显著降低（P＜0．01），同期研究组评分显著低于对照组（ P＜0．01）；治疗12周末，研究组总有效率为88．9％，对照组为66．7％，研究组总有效率显著高于对照组（ P＜0．05）。研究组不良反应发生率为17．8％，对照组为22．2％，研究组不良反应发生率低于对照组，但差异无显著性（P＞0．05）。结论帕罗西汀联合认知行为疗法治疗强迫症疗效显著，安全性高，优于单用帕罗西汀治疗。%Objective To explore the clinical efficacy and safety of paroxetine combined with cognitive be‐havior therapy (CBT ) in the treatment of obsessive compulsive disorder (OCD) .Methods Ninety OCD patients were randomly assigned to two groups ,both groups were treated with paroxetine ,and on this ba‐sis research group was plus CBT for 12 weeks .Efficacies were assessed with the Yale‐Brown Obsessive Compulsive Scale (Y‐BOCS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before and after treatment .Results Since the end of the 4th week the Y‐BOCS scores of both groups low‐ered more significantly compared with pretreatment (P<0 .01) ,those were significantly lower in research than control group in the corresponding periods (P<0 .01);at the end of the 12th week total effective rate was significantly higher in research than control group (88 .9% vs 66 .7% ,P<0 .05) .The incidence of ad‐verse reaction was lower in research than control group (17 .6% vs 22 .2% ) ,but difference wasn’t signifi‐cant (P>0 .05) .Conclusion Paroxetine combined with CBT has an evident effect and higher safety com‐pared with single paroxetine in OCD .
展开▼
