慢性精神分裂症患者加服利培酮治疗静息态功能磁共振研究

摘要

Objective:To explore the change of resting state functional magnetic resonance imaging(fM-RI)after combined risperidone treatment in chronic schizophrenia(SCH)patients. Method:Nine chronic SCH patients and 9 normal controls were recruited for this study. The data of socio-demographic variables,the Wisconsin card sorting test(WCST)and the resting fMRI at baseline and after treatment were collected,and the fMRI data were compared with normal controls. Results:Compared with the normal controls,SCH group showed significant brain regions in regional homogeneity( ReHo)and amplitude of low frequency fluctuation (ALFF)at baseline. After 12 weeks risperidone treatment,the significant brain regions were changed. Conclusion:There were significant difference in cognitive function and rest fMRI in chronic SCH patients. Ris-peridone may improve their cognitive function,and their brain imaging has correspondingly changed.%目的：应用功能磁共振（fMRI）分析慢性精神分裂症（SCH）患者加服利培酮治疗前后静息态大脑影像改变。方法：采集慢性 SCH 患者9例和正常对照组9名的一般人口学资料、临床资料及基线、治疗12周后静息态 fMRI 数据，对采集的数据进行统计学分析。结果：与正常对照组比较，SCH 组服药前静息态下局部一致性（ReHo）及低频振幅（ALFF）均有若干脑区存在差异；SCH 组在利培酮治疗12周后，ReHo 及 ALFF 发生改变。结论：慢性精神分裂症患者存在明显的认知功能异常及静息态脑fMRI 异常；慢性精神分裂症患者中加服或改服利培酮可改善患者的认知功能和阳性、阴性症状，且脑影像学有相应改变。