长期服用抗精神病药的男性精神分裂症患者骨密度与血清泌乳素的关系

摘要

目的：探讨长期服用抗精神病药的男性精神分裂症患者骨密度与血清泌乳素水平（ PRL）的关系。方法：将98例长期住院的男性精神分裂症患者按照PRL水平分为PRL升高组（＞390 mIU/L，66例）和PRL正常组（86~390 mIU/L，32例），测定两组患者的足后跟骨密度T值，并对两组结果进行分析比较。结果：与PRL正常组相比较，PRL升高组骨密度T值明显偏低（ t=3.58，P=0.00）。控制年龄因素后，骨密度T值与PRL水平呈负相关（ r=-0.101，P=0.043）；与体质量指数呈正相关（ r=0.199，P=0.012）；与病程无显著相关（ r=-0.066，P=0.414）。结论：长期服用抗精神病药的男性精神分裂症患者的骨密度与PRL水平呈负相关。%Objective:To explore the relationship between serum prolactin( PRL)level and bone mineral density( BMD)in the long-term antipsychotic-treated male patients with schizophrenia. Method:Ninety-eight male patients with schizophrenia were divided into the trial group(PRL>390 mIU/L,n=66)and the con-trol group( PRL between 86 ~390 mIU/L,n=32 ). The T-scores of the calcaneus bone mineral density were measured in both groups,and the between-group differences were compared. Results:The average T-score (BMD measure)of the trial group was significantly lower than that of the control group(t=3. 58,P=0. 00). A partial correlation analysis controlling for the age revealed a negative correlation between T-score and PRL and a positive correlation between T-score and body mass index(r= -0. 101,P=0. 043;r=0. 199,P=0. 012);whereas there was no significant correlation between T-scores and the course of disease( r = -0. 066,P =0. 414). Conclusion:There is a negative correlation between the BMD and the serum level of prolactin in the long-term antipsychotic-treated male patients with schizophrenia.