经颅微电流刺激治疗难治性儿童抽动秽语综合征患者6个月临床观察

摘要

Objective:To evaluate the efficacy and safety of the cranial electrotherapy stimulation( CES) in children with refractory Tourette syndrome. Method:Twenty one children with Tourette syndrome were treated with CES. The first 12 weeks applied continued drugs with the addition of CES for treatment,and then gradually removed the drugs to a single CES treatment. The efficacy and safety were evaluated with The Yale Global Tic Severity Scale( YGTSS)and Treatment Emergent Symptom Scale( TESS),respectively,before treat-ment and at the end of 4 and 24 weeks of treatment. Results:The YGTSS total scores and each factor score after 4 weeks and 24 weeksˊtreatment were lower than those of before treatment(p﹤0. 01),the efficacy of treat-ment after 4 weekend and 24 weekend was 47. 62% and 80. 95%,respectively;the adverse reaction of before 4 weeks and after treatment was significantly greater than that 24 weeks later. Conclusion:CES is a safe and effective treatment for refractory children TS,and could be used as a choice for physical therapy for children’s refractory Tourette syndrome.%目的：评价经颅微电流刺激（ CES）治疗难治性儿童抽动秽语综合征（ TS）的疗效和安全性。方法：对21例TS患儿，前12周以正在服用的药物加CES，12周后逐渐撤去药物，单一CES治疗。在治疗前和治疗4周及24周采用耶鲁综合抽动严重程度量表（ YGTSS）及治疗中出现的症状量表（ TESS）评定其疗效和安全性。结果：治疗4周及治疗24周YGTSS总分及各因子分均显著低于疗前，（ p均﹤0.01）；治疗4周及24周显效率分别为47.62%及80.95%；治疗24周不良反应显著小于疗前及治疗4周。结论：CES能安全有效地治疗难治性TS。