首发抑郁症患者血清胶质纤维酸性蛋白浓度与认知功能的关系

摘要

Objective:To explore the relationship between the serum glial fibrillary acidic protein ( GFAP)level and cognitive function of first-episode depression patients. Method:Serum concentration of GFAP of patients with first-episode depression( study group)and normal people( control group)with 45 cases in each was measured with enzyme linked immunosorbent assay. Cognitive function of each patients was assessed using Wisconsin card sorting test. Correlation of serum GFAP concentration with symptoms of depression and cognitive function damage was analyzed. Results:The concentration of serum GFAP was significantly in-creased in the study group compared with the control group(t=12. 72,p﹤0. 05). Correlations between the ser-um GFAP levels of the study group and HAMD total score and its each factor score were not statistically signifi-cant. GFAP showed negative correlation with somatization anxiety of HAMA(r=0. 312,p﹤0. 05). The correct numbers and numbers of categories completed of the study group were less than those of the control group( t=-3. 349,t= -3. 349;all p﹤0. 05). The study group demonstrated more continuous errors and random errors than the control group(t=4. 333,p﹤0. 05). In the study group,the serum level of GFAP was negatively corre-lated with the correct numbers and numbers of categories(r=0. 527,r=0. 527,all p﹤0. 01),and positively associated with the continuous errors(r=0. 450,p﹤0. 01). Correlation between serum GFAP level of the study group and the illness duration had no statistical significance(r=0. 129,p﹥0. 05). Conclusion:First-epi-sode depression patients have serum GFAP elevation and cognitive impairment,and the highter the serum GFAP concentration is,the more serious the cognitive function impairment.%目的：探讨首发抑郁症患者血清胶质纤维酸性蛋白（ GFAP ）浓度与认知功能的关系。方法：以酶联免疫吸附技术测定首发抑郁症患者（患者组）45例和正常人（对照组）45名血清GFAP浓度，使用威斯康星卡片分类测验检测两组的认知功能，分析血清GFAP浓度和认知功能损害的关系。结果：患者组血清GFAP浓度较对照组显著升高（ t=12.72，p﹤0.05）；患者组血清GFAP浓度与HAMD总分及各因子分相关无统计学意义，与HAMA因子躯体化焦虑呈负相关（ r=0.312，p﹤0.05）；患者组正确数、完成分类数较对照组少（ t=-3.349，t=-3.349；p均﹤0.05）；持续错误数，随机错误数较对照组多（t=4.333，p﹤0.05）；患者组血清GFAP浓度与正确数、完成分类数呈负相关（r=0.527，r=0.527；p均﹤0.01），与持续错误数呈正相关（ r=0.450，p﹤0.01）；患者组血清GFAP浓度和病程之间相关无统计学意义（ r=0.129，p﹥0.05）。结论：首发抑郁症患者存在血清GFAP浓度升高，认知功能损害，血清GFAP浓度越高，认知功能损害越严重。