男性康复期精神分裂症患者基于事件的前瞻记忆研究

摘要

Objective:To investigate the event-based prospective memory(EBPM)in male remitted schizophrenic patients. Method:The intelligence and prospective memory function were assessed in 42 male remitted schizophrenic patients(case group)and 42 normal control(control group)by Wechsler adult intelli-gence test and event-based prospective memory(EBPM)experimental paradigm. Results:The IQ in the case group(91.85 ± 12.90)and the control group(96.15 ± 12.35)showed no significant difference.In EBPM test, the reaction time in the case group[(1075.92 ± 36.65)ms]was significantly longer than the control group [(889.55 ± 36.65)ms];the total correct rate[(88.10 ± 1.90)%]and the correct rate of prospective memory [(77.57 ± 22.86)%]were significantly lower than those in the control group[(95.40 ± 1.90)%,(93.76 ± 6.39)%,all P<0.001]. Conclusion:Prospective memory function defects in the in male remitted schizo-phrenic patients may be primary lesion of the disease.%目的:探讨男性康复期精神分裂症患者前瞻记忆状况. 方法:应用韦氏智力测验及基于事件的前瞻记忆(EBPM)实验范式测评并比较男性康复期精神分裂症患者(康复期患者组,42例)和男性健康志愿者(健康对照组,42名)的智力及前瞻记忆功能. 结果:康复期患者组总体智商(91.85 ± 12.90)与健康对照组(96.15 ± 12.35)比较差异无统计学意义;康复期患者组EBPM反应时[(1075.92 ± 36.65)ms]明显长于健康对照组[(889.55 ± 36.65)ms],总正确率[(88.10 ± 1.90)%]及前瞻记忆任务正确率[(77.57 ± 22.86)%]明显低于健康对照组[(95.40 ± 1.90)%,(93.76 ± 6.39)%](P均<0.001);两组进行中任务的正确率比较差异无统计学意义. 结论:男性康复期精神分裂症患者的前瞻记忆功能缺陷可能是该疾病的原发性损伤.