血清心肌肌钙蛋白I诊断川崎病急性期心肌损伤的临床价值

摘要

为探讨血清心肌肌钙蛋白I(cTnI)诊断川崎病(KD)急性期心肌损伤的临床价值。检测KD组(n=40)及对照组(n=23)患儿血清cTnI、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)、乳酸脱氢酶(LDH)与谷草转氨酶(GOT)浓度。结果显示：①KD组与对照组血清CK、LDH、GOT浓度无显著性差别(P＞0.05)；而血清cTnI、CK-MB浓度明显高于对照组水平(P＜0.001)。②在诊断KD患儿急性期心肌损伤上cTnI优于CK-MB(P＜0.05)，。结果表明：cTnI与CK-MB对KD患儿急性期心肌损伤有诊断价值；与CK-MB比较，cTnI具有高特异性、灵敏度。%To explore the clinical significance of serum cardiac troponin I (cTnI) for the detection of myocardial injury in children with Kawasaki disease (KD) in acute stage, the levels of serum cTn I, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactic dehydrogenase (LDH) and glutamic oxalacetic transaminase (GOT) were determined in 40 children with KD and 23 controlled children without heart disease, respectively. The results showed that the levels of serum cTn I and CK-MB in the KD group were significantly higher than those in the controlled group (P＜0.001),while no obviously differences of CK, LDH and GOT were noticed between two groups (P＞0.05). cTn I was more sensitive comparing to CK-MB for the detection of myocardial injury (P＜0.05). It is concluded that the determination of cTn I and CK-MB will be available for the diagnosis of myocardial injury in children with KD in acute stage, and the determination of cTn I is more sensitivity and specificity comparing to CK-MB.