新生儿尿路感染研究进展

摘要

尿路感染(urinary tract infection,UTI)是新生儿最常见感染之一.新生儿UTI 可引起不可逆性肾损伤,尤其是伴有膀胱输尿管反流(vesicoureteric reflux,VUR)时,更易造成肾实质损伤,最终造成肾性高血压、蛋白尿及肾衰竭.若未能及时明确病因、诊断与治疗,感染可侵及各脏器,引起新生儿败血症、化脓性脑膜炎、病理性黄疸等并发症.因此,明确新生儿UTI 高危因素、易感病原菌及其重要,及时诊断、治疗尤为重要.%Objectives Urinary tract infection (UTI) is one of the most common infections in neonates. Neonatal UTI can cause irreversible kidney damage which is especially more likely to happen in the presence of coexisting vesicoureteric reflux (VUR), and ultimately lead to renal hypertension, proteinuria and renal failure. If UTI cannot be diagnosed and treated timely, it can cause neonatal sepsis, purulent meningitis, pathological jaundice and other complications. Therefore, it is extremely important to pinpoint the risk factors and susceptible pathogens of neonatal UTI and to timely diagnose and treat the neonatal UTI.