Objectives To investigate the rational treatment strategy of hepatoblastoma (HB) in children. Methods Clinical data and follow-up of 25 children with HB admitted from February 2009 to March 2013 were retrospectively analyzed. Results Twenty-five children with newly diagnosed HB (14 males and 11 females) were enrolled. The median age on diagnosis was 25 months (3-92 months);In 18 of 25 cases with complete resection of the primary tumor, 17 cases survived. Only 1 of 7 cases with incomplete resection survived. The survival rate in children with complete resection of primary tumor is significantly higher than those without complete resection (P<0.05). The survival rate in children of stage I or II is significantly higher than the children of stage III or IV (P<0.05). Conclusions Complete tumor resection is the cornerstone of therapy for long-term disease-free survival in HB patients. Treatment strategy remains to be further improved for children with recurrent and metastatic HB.%目的:总结儿童肝母细胞瘤(HB)的治疗效果,探讨合理治疗策略。方法回顾性分析2009年2月至2013年3月初治的HB患儿的临床及随访资料。结果入选25例初治HB患儿,男14例、女11例,中位发病年龄为25个月(3~92个月)。其中原发肿瘤完整切除18例,存活17例;未完全切除7例,仅1例存活;原发肿瘤完整切除者的生存率明显高于未完整切除者,Ⅰ、Ⅱ期患儿生存率明显高于Ⅲ、Ⅳ期患儿,差异均有统计学意义(P均<0.05)。结论手术完整切除是所有临床分期的HB患儿获得长期无瘤生存的关键,对于复发和转移的HB患儿的治疗策略有待进一步完善。
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