首页> 中文期刊> 《临床儿科杂志》 >肺炎支原体肺炎患儿外周血IL-10/IL-17表达与肺功能变化的相关性研究

肺炎支原体肺炎患儿外周血IL-10/IL-17表达与肺功能变化的相关性研究

         

摘要

ObjectiveTo evaluate the correlation of peripheral IL-10/IL-17 expression and pulmonary function in children withMycoplasma pneumoniae pneumonia (MPP).MethodsChildren with MPP (n=66) were recruited and divided into MPP gasp groups (n=31) and MPP no-gasp group (n=35) based on whether pulmonary wheezing sound exists. Another 30 healthy children were recruited as control group. ELISA was used to detect the level of interleukin - 6 (IL - 6) and transforming growth factor-β (TGF-β). The peak expiratory lfow (PEF), forced expiratory volume in 1 s (FEV1), forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) and lung capacity maximum expiratory lfow (V75, V50, V25)were detected by pulmonary function instrument.ResultsThe serum IL-10 level of MPP gasp groups, MPP no-gasp group and control group were(8.1±1.8) ng/L,(13.3±2.0)ng/L and(18.4±1.7)ng/L, respectively; the serum IL-17 level were(23.8±2.3)ng/L,(16.2±1.5)ng/L and (11.4±1.0)ng/L, respectively; which showed signiifcant differences between each group(P<0.05). The PEF, FEV1 and FEV1/FVC of MPP gasp groups were(71.4±5.7)%,(71.8±6.3)% and 72.5±9.6; and those of MPP no-gasp group were(95.3±7.8)%, (96.2±10.5)% and 85.3±4.5; which showed signiifcant differences between the two groups(P<0.05). The V75, V50 and V25 were(74.7±5.0)%,(45.2±10.3)% and(38.3±8.7)%, and those of MPP no-gasp group were(85.6±4.2)%,(75.9±9.5)% and (66.1±12.5)%. Pearson correlation analysis showed that PEF, FEV1, V75, V50 and V25 had positive correlation(P˂0.05)with the level of IL-10 and f IL-17 (bothP˂0.05).ConclusionMPP children have IL-10/IL-17 imbalance, and the expression of IL-10/IL-17 was correlated with pulmonary function changes.%目的:探讨肺炎支原体肺炎(MPP)患儿外周血IL-10/IL-17表达与肺功能变化的相关性。方法选取66例MPP患儿,依据是否闻及肺部哮鸣音分为MPP喘息组(n=31)和MPP非喘息组(n=35),选取健康体检儿童30例为对照组。采用ELISA法检测各组IL-10、IL-17水平;采用肺功能检测仪检测呼气高峰流量(PEF)、第1秒时间肺活量(FEV1)、第1秒时间肺活量/用力肺活量(FEV1/FVC)及肺活量最大呼气流速(V75,V50,V25)。结果 MPP喘息组、非喘息组与对照组三组相比较,IL-10及IL-17差异有统计学意义(F=34.788、30.957,P均<0.05),其中MPP喘息组和MPP非喘息组血清IL-17水平均高于对照组,差异有统计学意义(P均<0.05);MPP喘息组和MPP非喘息组血清IL-10水平均低于对照组,差异有统计学意义(P均<0.05)。与MPP非喘息组相比较,MPP喘息组PEF、FEV1、FEV1/FVC、V75、V50和V25均明显降低,差异具有统计学意义(t=3.268~5.362,P均<0.05)。Pearson相关分析显示,MPP患儿血清IL-10表达水平与PEF、FEV1、V75、V50、V25呈正相关(r=0.285~0.492,P<0.05);IL-17表达水平与PEF、FEV1、V75、V50、V25呈负相关(r=–0.327~–0.451,P<0.05)。结论MPP患儿存在IL-10/IL-17免疫平衡异常现象,且IL-10/IL-17表达与肺功能变化存在相关性。

著录项

相似文献

  • 中文文献
  • 外文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号