首页> 外国专利> method of treating an autoimmune disorder, use of a tccr agonist, methods for increasing expression of il-10 and socs3 in lymphocytes, method for selection of tccr agonists, monoclonal antibody, hybridoma cell line, methods of treatment or suppression of an immune response and method of inhibiting the production of il-17, il-6 or gm-csf

method of treating an autoimmune disorder, use of a tccr agonist, methods for increasing expression of il-10 and socs3 in lymphocytes, method for selection of tccr agonists, monoclonal antibody, hybridoma cell line, methods of treatment or suppression of an immune response and method of inhibiting the production of il-17, il-6 or gm-csf

机译:治疗自身免疫性疾病的方法,使用tccr激动剂,增加淋巴细胞中il-10和socs3表达的方法,选择tccr激动剂,单克隆抗体,杂交瘤细胞系的方法,治疗或抑制免疫应答的方法和抑制il-17,il-6或gm-csf产生的方法

摘要

TREATMENT METHOD OF AN AUTOIMMUNE DISTURBANCE, USE OF A TCCR AGONIST, METHODS FOR INCREASING IL-10 AND SOCS3 EXPRESSION IN LYMPHOCYTES, METHOD FOR SELECTING TCCR AGENTS, MONOCLONAL DENTAL HYDROLONOUS ANTIBODY, Suppression of an immune response and method of inhibiting IL-17, IL-6 or GM-CSF production. The present invention relates to methods of treating autoimmune disorders. In one embodiment, the present invention is directed to methods of treating autoimmune disorders comprising administering a TCCR agonist. In one embodiment, the autoimmune disorder is less partially mediated by a Th1 response. In one embodiment, the autoimmune disorder is at least partially mediated by CD8 + T cell proliferation.
机译:自身免疫干扰的治疗方法,使用TCCR激动剂,增加淋巴细胞中IL-10和SOCS3表达的方法,选择TCCR试剂的方法,单核口腔亲水性抗体,抑制免疫反应和抑制IL-17 IL的方法-6或GM-CSF生产。本发明涉及治疗自身免疫疾病的方法。在一个实施方案中,本发明涉及一种治疗自身免疫疾病的方法,其包括施用TCCR激动剂。在一个实施方案中,自身免疫疾病较少部分地由Th1应答介导。在一个实施方案中,自身免疫疾病至少部分地由CD8 + T细胞增殖介导。

著录项

  • 公开/公告号BRPI0517202A

    专利类型

  • 公开/公告日2008-09-30

    原文格式PDF

  • 申请/专利权人 GENENTECH INC.;

    申请/专利号BR2005PI17202

  • 发明设计人 NICO GHILARD;FREDERIC DESAUVAGE;

    申请日2005-12-16

  • 分类号C07K16/28;A61K38/20;

  • 国家 BR

  • 入库时间 2022-08-21 20:08:43

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号