Objective To investigate the serum levels of interleukin ( IL)-6, IL-10, C-reactive protein ( CRP) on the value of early diagnosis of infection after total joint replacement. Methods Hip, knee arthroplasty ( observation group) in 38 cases, and the establishment of health personnel control (control group) 34 cases were enrolled. All ca-ses were detected with chemiluminescence immunoassay method for IL-6, IL-10 level, CRP level was determined by immune turbidimetry, changes of 1, 3, 5, 7 d, IL-6, IL-10, CRP level in serum observation of 1 d patients before and after joint replacement. Results Serum IL-6, IL-10, CRP levels were (3. 24 ± 0. 56) ng/L, (8. 15 ± 2. 28) ng/L, (1. 68 ± 0. 31) mg/L. Preoperative 1 d observation group compared with the control group, no significant differences in the level of IL-6, IL-10, CRP (P>0. 05). After 1, 3, 5 d were observed in group IL-6, IL-10, CRP levels were Significantly higher than those in the control group, the difference was statistically significant ( P <0. 05). Postoperative 7 d were observed in group IL-6,the level of IL-10 compared with the control group had no sig-nificant difference (P>0. 05), CRP levels were significantly higher than those in the control group (P<0. 05). 1 d patients with serum IL-6, IL-10 levels were significantly higher in the patients in the observation group, after 3, 5, 7 d decreased (P<0. 05), In 1, 3 d in patients with serum CRP level gradually increased after the operation, after op-eration in 5, 7 d decreased gradually (P<0. 05),(P<0. 05), no significant postoperative 7 d in patients with ser-um IL-6, IL-10 levels and operation before the 1 d difference (P>0. 05), higher than the preoperative 1 d serum CRP level after 7 d (P<0. 05). Conclusions Serum IL-6, IL-10 and CRP can early reflect the inflammatory status after total joint replacement, but IL-6, IL-10 are more sensitive, accurate, valuable in early diagnosis of infection af-ter total joint replacement.%目的：探讨血清白介素( IL)-6、IL -10、C-反应蛋白( CRP)对全关节置换术后早期感染的诊断价值。方法选择人工髋、膝关节置换术(观察组)患者38例,同时设立健康人员对照(对照组)34例,以化学发光免疫法测定IL-6、IL-10水平,采用免疫比浊法测定CRP水平,观察患者关节置换术前1 d及术后1、3、5、7d血清IL-6、IL-10、CRP水平的变化。结果对照组血清IL-6、IL-10、CRP水平分别为(3.24±0.56) ng/L、(8.15±2.28)ng/L、(1.68±0.31) mg/L。术前1 d观察组与对照组比较,IL-6、IL-10、CRP水平差异无统计学意义(P>0.05)。术后1、3、5 d观察组IL-6、IL-10、CRP水平均明显高于对照组,差异有统计学意义(P<0.05)。术后7 d观察组IL-6、IL-10水平与对照组比较无明显差异( P>0.05), CRP水平明显高于对照组( P<0.05)。观察组患者术后1 d血清IL-6、IL-10水平明显升高,术后3、5、7 d逐渐下降( P<0.05),术后1、3 d血清CRP水平逐渐增加,术后5、7 d逐渐下降(P<0.05),术后7d患者血清IL-6、IL-10水平与术前1 d比较差异无统计学意义(P>0.05),术后7 d血清CRP水平高于术前1 d(P<0.05)。结论血清IL-6、IL-10及CRP均能于早期反映全关节置换术后炎症状态,但IL-6、IL-10更敏感、准确率更高,对早期诊断全关节置换术后感染更有价值。
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