目的：探讨关节内应用氨甲环酸( TXA)对减少全膝关节置换( TKA)术后失血量及输血率的疗效。方法将50例行单侧TKA患者随机分为TXA组(25例，将1 g TXA融入50 ml 生理盐水关节内注射)及对照组(25例，将50 ml 生理盐水关节内注射)，比较两组输血率、总引流量、总失血量、术后血红蛋白和红细胞比容、住院时间、并发症等指标。结果患者均获得随访，时间8~12个月。 TXA组患者输血率、总引流量、总失血量均低于对照组，术后第1、3、5天血红蛋白和红细胞比容均高于对照组，差异均有统计学意义( P<0．05)。两组术后各出现1例下肢深静脉血栓；两组的并发症发生率、住院时间及VAS评分比较差异均无统计学意义(P>0．05)。结论 TKA术中局部应用TXA能显著减少术后失血量及输血率。%Objective To investigate the effect of tranexamic acid( TXA) to reduce blood loss during the perioperative period to undergo primary unilateral total knee arthroplasty. Methods Fifty patients underwent primary unilateral TKA were randomly divided into the TXA group (25 cases,1 g TXA was placed into 50 ml normal saline, applied into tranexamic) and control group (25 cases, 50 ml normal saline, applied into tranexamic). Both groups were com-pared with the total drainage,total blood loss volume, postoperative hemoglobin, hematocrit, length of stay, and post-operative complications. Results All patients were followed up for 8~12 months. In the TXA group, the transfusion rate,total blood loss, postoperative drainage volume was less than those in the control group, Hg and HCT were high-er than control group at 1,3,5 d postoperation, the differences were statistically significant(P<0. 05). Lower limb venous thrombosis was found in 1 patient in both TXA group and control group. There was no significant difference in complications, length of stay and VAS (P>0. 05). Conclusions Topically applied TXA is effective in reducing the blood lose and blood transfusion rate following total knee arthroplasty.
展开▼
