开颅术后并发泛耐药鲍曼不动杆菌性颅内感染病例报告并文献复习

摘要

目的 探讨泛耐药鲍曼不动杆菌性颅内感染的治疗方案.方法 对1例脑出血术后合并泛耐药鲍曼不动杆菌性颅内感染患者的治疗过程进行回顾分析,重点从药物选择、给药剂量等方面进行药物治疗过程分析.结果 通过将抗感染治疗方案调整为替加环素+头孢哌酮舒巴坦+米诺环素静脉给药,联合替加环素鞘内、脑室内给药,患者的颅内感染最终得到有效控制.结论 替加环素鞘内及脑室内给药,对泛耐药鲍曼不动杆菌引起的颅内感染可获得较好的治疗效果.%Objective To explore the treatment scheme for intracranial infection induced by extensively drug resistant Acinetobacter baumanni (XDRA) after craniotomy.Methods The treatment process of a patient who acquired intracranial infection induced by XDRA was analysed retrospectively,which involved choice and dose of antibacterials.Results The intracranial infection was controlled effectively at the end by changing the antibiotics scheme to intravenous "tigecycline+cefperazone-sulbactam+minocycline",combined with intrathecal and intraventricular tigecycline injection.Conclusion Intrathecal and intraventricular tigecycline injection could achieve good effect of controlling intracranial infection.