Alzheimer病和路易体痴呆患者血清及脑脊液金属元素含量的变化

摘要

Objective To investigate the content changes of metal elements concentrations of magnesiumcopper ( Cu) , (iron( Fe) ,calcium( Ca) ,Mg) ,zinc( Zn) ,lead( Pb) and manganese ( Mn) in serum and CSF in patients with Alzheimer disease (AD) and dementia with Lewy body(DLB). Methods The contents of Cu, Fe,Ca,Mg,Zn,Pband Mnin serum and CSF were determined by inductively coupled plasma mass spectrometry in 40 AD patients,20 DLB patients and 18 healthy controls. Results The content of serum Zn in DLB group was significantly lower than AD and normal control groups (all P ＜ 0. 05). The contents of CSF Ca in AD and DLB groups were significantly higher than normal control group (all P ＜ 0. 05). The content of CSF Fe in AD group was significantly higher than DLB and normal control groups (all P ＜ 0. 05 ). Conclusions There is disequilibrium of metal elements Zn, Feand Ca homeostasis of the body or nervous system in AD and DLB patients. Those may be help for assessing the oxidative stress injury of nervous system in AD,DLB patients,and exploring the pathogenesis.%目的 探讨Alzheimer病(AD)和路易体痴呆(DLB)患者血清及CSF中金属镁铜(Cu)、铁(Fe)、钙(Ca)、(Mg)、锌(Zn)、铅(pb)和锰(Mn)含量的变化.方法 使用电感耦合等离子体质谱法检测40例AD患者、20例DLB患者及18名正常对照者血清及CSF中Cu、Fe、Ca、Mg、Zn、Pb及Mn的含量.结果 (1) DLB组血清Zn含量明显低于AD组及正常对照组(均P＜0.05)；(2)AD组及DLB组CSF Ca含量明显高于正常对照组(均P ＜0.05)；(3)AD组CSF Fe含量明显高于DLB组及正常对照组(均P＜0.05).结论 AD及DLB患者体内或神经系统存在金属元素Zn、Fe、Ca稳态失衡,这些可能有助于评估AD和DLB患者神经系统的氧化应激损伤及对发病机制的研究.