壳聚糖、磷脂酰胆碱对轻度认知功能障碍患者脑组织氢质子磁共振波谱成像的影响

摘要

目的 观察壳聚糖、磷脂酰胆碱对轻度认知功能障碍(MCI)患者海马氢质子磁共振波谱成像(1H-MRSI)的影响.方法 对15例MCI患者(MCI组)和15名正常老年人(正常对照组)进行海马1H-MRSI检查.给予MCI组患者壳聚糖、磷脂酰胆碱治疗2个月后对其进行复查,比较N-乙酰天门冬氨酸(NAA)/肌酸(Cr)、胆碱(Cho)/Cr、肌醇(mI)/Cr的比值.结果 与正常对照组相比,MCI组服药前、后NAA/Cr比值显著降低,mI/Cr比值显著升高(均P＜0.05),Cho/Cr的差异无统计学意义.MCI组治疗后的NAA/Cr比值较治疗前明显升高(P<0.05),mI/Cr比值明显降低(P＜0.05),Cho/Cr比值治疗前后的差异无统计学意义.结论 1H-MRSI显示,壳聚糖和磷脂酰胆碱能改善脑组织的代谢,可能对MCI有一定的治疗作用.%Objective To observe the influence of chitosan and phosphatidylcholine on proton MR spectroscopis imaging ('H-MRSI) of brain tissue in patients with mild cognitive impairment (MCI). Methods 'H-MRSI of hippocampus was performed in the 15 MCI patients (MCI group) and 15 normal olders (NC group). The MCI group rechecked after 2 months of therapy with chitosan and phosphatidylcholine. And the ratios of N-acetyl aspartate (NAA)/creatine ( Cr) , choline (Cho)/Cr and myo-inositol (mI)/Cr were compared. Results Compared with NC group, the ratios of NAA/Cr in MCI group at pre and post therapy were significantly lower ( all P < 0. 05 ) , the ratios of ml/Cr were significantly higher ( all P < 0. 05 ) , and there was no statical difference in the ratio of Cho/Cr between them. The ratio of NAA/Cr of post therapy in MCI group was significantly higher than pre therapy ( P < 0. 05 ) , the ratio of ml/Cr was significantly lower ( P < 0. 05 ) ; and there was no statistical difference in the ratio of Cho/Cr between pre and post therapy. Conclusion ' H-MRSI shows that chitosan and phosphatidylcholine can improve the metabolism of brain tissue and maybe useful for MCI.