抗菌肽对金黄色葡萄球菌抑制作用的研究

摘要

Objective To explore the inhibitory effect of antimicrobial peptide s-Thanatin against Staphylococcus aureus by broth microdilution. Methods The activity of s - Thanatin against Staphylococcus aureus was evaluated by the minimum inhibitory concentration (MIC). Results The results demonstrated that the MIC of s- Thanatin against Staphylococcus aureus was 50 mg/L. Conclusion A higher concentration of s- thanatin is necessary to inhibit common pathogenic Staphylococcus aureus. Therefore, the chemical structure of antibacterial peptide Thanatin should be modified to improve the activity against Staphylococcus aureus.%目的 探讨抗菌肽S-Thanatin对金黄色葡萄球菌的抑制效果.方法 采用肉汤微量稀释法研究抗菌肽S-Thanatin对金黄色葡萄球菌的最低抑菌浓度(MIC).结果 抗菌肽S-Thanatin对金黄色葡萄球菌MIC是50 mg/L.结论 抗菌肽S-Thanatin对临床常见的金黄色葡萄球菌需要较高浓度才有抑制作用,因此为进一步提高其抗金黄色葡萄球菌活性,需要对抗菌肽S-Thanatin的化学结构进行改进.