生长抑素治疗老年急性糜烂出血性胃炎大出血患者的疗效评价

摘要

Objective To observe the effect of somatostatin in the treatment of elderly patients with acute erosive hemorrhagic gastritis bleeding.Methods Sixty-four patients who met the diagnostic criteria for acute erosive hemorrhagic gastritis were included in the study.They were randomly divided into treatment group (n =32) and control group (n =32).Two groups of patients were treated with symptomatic and supportive treatment such as acid suppression,hemostasis,and rehydration.The treatment group received additional somatostatin.Then the effect of treatment,blood stopping time,one-week hemorrhage recurrence rate,length of stay,and hospital costs were recorded and compared.Results Hemostasis rate of the treatment group within three days was 93.75 ％,and it was 71.87 ％ of the control group.The difference between the two groups was statistically significant (P ＜ 0.05).One-week rebleeding rate of the treatment group was 0.00 ％,and it was 6.25 ％ in the control group.The difference was statistically significant (P ＜ 0.05).Conclusion The effect of somatostat in treatment of elderly patients with acute erosive hemorrhagic gastritis bleeding is significant.It can rapidly stop bleeding,shorten hospital stays,and lower rebleeding rate and mortality rate of gastrointestinal bleeding.Thus somatostatin is worthy of clinical application.%目的 探讨生长抑素治疗老年急性糜烂出血性胃炎大出血患者的疗效.方法 选取符合诊断标准的老年急性糜烂出血性胃炎大出血患者64例,随机分为治疗组和对照组,每组32例.2组患者均给予抑酸、止血、补液等对症治疗,治疗组在此基础上加用生长抑素.记录并比较2组治疗效果、出血停止时间、1周内出血复发率、住院时间、住院费用等情况.结果 治疗组72 h内止血率为93.75％,对照组为71.87％,差异有统计学意义(P＜0.05);治疗组1周内再出血率为0.00％,对照组为6.25％,差异有统计学意义(P＜0.05).结论 生长抑素治疗老年急性糜烂出血性胃炎大出血疗效显著,止血迅速,能显著缩短住院时间,降低再出血率及消化道大出血死亡率,值得临床推广应用.