奥尔芬联合间苯三酚治疗急性胆绞痛疗效分析

摘要

目的 评价奥尔芬联合间苯三酚治疗胆绞痛的疗效及安全性.方法 将2011年3月-2012年3月于本院就诊的120例胆绞痛患者随机分为4组,每组30例.A组给予奥尔芬+间苯三酚,B组给予奥尔芬,C组给予间苯三酚,D组给予山莨菪碱.比较各组镇痛效果及不良反应发生率.结果 A、B、C、D组的镇痛总有效率分别为100.0％、76.7％、66.7％、33.3％.A组与B、C、D组镇痛效果相比较,差异有统计学意义(P＜0.05)；B组与C组相比较,差异无统计学意义(P＞0.05)；B组及C、D组相比较,差异均有统计学意义(P＜0.05).A、B、C、D组的不良反应发生率分别为6.7％、6.7％、3.3％、53.3％.A、B、C组组间比较,差异无统计学意义(P＞0.05)；A、B、C组与D组相比较,差异均有统计学意义(P＜0.05).结论 奥尔芬联合间苯三酚治疗急性胆绞痛,疗效确切,不良反应少,值得临床推广应用.%Objective To evaluate the curative effect and safety of olfen and phloroglucinol in patients with acute biliary colic.Methods A total of 120 patients with acute biliary colic of our hospital from March 2011 to March 2012 were divided into four groups randomly,group A (Olfen and Phloroglucinol,n =30),group B (olfen,n =30),group C (phloroglucinol,n =30),and group D (anisodarine,n =30).The analgesic effect and adverse reaction of four groups were observed.Results The total effectiveness rates of analgesia in groups A,B,C and D were 100 ％,76.7％,66.7％ and 33.3％,respectively.The differences were statistically significant between group A and other three groups (P ＜ 0.05).There were no statistical differences between group B and group C (P ＞ 0.05),and the differences were statistically significant between group B and group C and D (P ＜ 0.0 5).The adverse reaction rates of groups A,B,C and D were 6.7 ％,6.7 ％,3.3 ％ and 53.3 ％,respectively.There were no statistical differences in groups A,B and C (P ＞ 0.05),and the differences were statistically significant between group D and other three groups (P ＜ 0.05).Conclusion Combined application of olfen and phloroglucinol in patients with acute biliary colic results in noticeable analgesic effect and fewer side effects.Thus it is worth clinical applications.