Objective To explore the effect of ursodeoxycholic acid combined with diammo-nium glycyrrhizinate in the treatment of primary biliary cirrhosis. Methods Thirty- eight patients of with primary biliary cirrhosis (PBC) were randomly divided into treatment group and control group. The treatment group received ursodeoxycholic acid combined with diammonium glycyrrhizinate treatment, and the control group ursodeoxycholic acid treatment. The treatment course was one month. Changes between patients in the two groups were compared in liver function index, clinical symptoms and adverse reactions. Results After treatment, liver function indexes of the patients in the two groups, and the clinical curative effect significantly improved . The clinical efficacy indexes and liver function in the ursodeoxycholic acid combined with diammonium glycyrrhizinate treatment group were better than those in the control group. No obvious adverse reactions were observed in two groups. Conclusion Ursodeoxycholic acid combined with diammonium glycyrrhizinate in the treatment of primary biliary cirrhosis is safe and effective.%目的 探讨熊去氧胆酸联合甘草酸二铵治疗原发性胆汁性肝硬化的疗效.方法 选择本院原发性胆汁性肝硬化(PBC)患者38例,随机分为治疗组与对照组,治疗组予熊去氧胆酸联合甘草酸二铵治疗,对照组单用熊去氧胆酸治疗,疗程1月,比较2组患者肝功能指标变化、临床症状及不良反应的发生情况.结果 治疗后2组患者肝功能各项指标、临床疗效均较治疗前有明显改善(P＜0.05),而熊去氧胆酸联合甘草酸二铵治疗组肝功能各项指标、临床疗效均优于对照组,2组均无明显不良反应发生.结论 熊去氧胆酸联合甘草酸二铵治疗活动性原发性胆汁性肝硬化有效、安全.
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