血清胱抑素C水平对缺血性心力衰竭患者近期预后的影响

摘要

Objective To explore the influence of serum Cystatin C(CysC)level on short-term prognosis of patients with ischemic heart failure(IHF).Methods Serum level of CysC,BUN and Scr in the 76 patients with IHF and 46 normal people were detected.The clinical outcomes, major cardiac events,mortality during hospitalization,re-admission rate were compared.Results The level of serum CysC in heart function class I group was significantly better than that in the con-trol group (P <0.05).It increased with the higher class of NYHA heart functional classification (class Ⅳ cardiac function >class Ⅲ>class Ⅱ,respectively)(P <0.05).Compared with normal CysC group,the major cardiac events,mortality and re-admission rate were significantly higher in high CysC group(P <0.05).Conclusion Serum level of CysC is closely related with short-term prognosis of patients with IHF,and it is a predictor for major cardiac events and death in patients with IHF.%目的：探讨血清胱抑素 C （CysC）水平与缺血性心力衰竭患者近期预后的关系。方法测定76例缺血性心衰患者及46例正常人血清 CysC、BUN 和 Scr 浓度等指标，记录缺血性心衰患者住院期间及出院3个月内主要心血管事件、病死率和再入院率。结果心功能 I 级者血清 CysC 水平较对照组显著升高（P ＜0．05），随着 NYHA 心功能分级级别增高，血清 CysC水平明显升高（P ＜0．05）。缺血性心衰患者高血清 CysC 组患者心血管事件、住院病死率、3个月病死率和再入院率都明显增加，与血清 CysC 正常组比较差异有统计学意义（P ＜0．05）。结论血清 CysC 水平与缺血性心衰患者近期预后有密切的关系，血清 CysC 可作为缺血性心衰患者近期心血管事件及死亡的预测因子。