生物活性玻璃结合浸浴治疗烧伤残余创面的疗效评价

摘要

Objective To explore the therapeutic effect of bioactive glass combined with bath therapy on treatment of residual burn wounds.Methods 60 patients with residual burn wounds were randomly divided into trial group and control group,30 cases in each group.The trial group was treated with bioactive glass and bath therapy,while the control group was treated with iodophor gauze and bath therapy.The wound healing,growth of granulation tissue and bacteria de-tection were compared on 7th,14th and 21st day after treatment,and side effects were monitored during the treatment.Results In trial group,7 patients healed on 14th day and 8 patients healed on 21st day.In control group,one patient healed on 14th day,3 patients healed on 21st day.Ac-cording to the standards of wound healing,the total effective rate in the trial group was 93.3%, which was significantly higher than 56.7% in the control group (P <0.01).Staphylococcus au-reus,staphylococcus aureus,pseudomonas aeruginosa,escherichia coli,klebsiella pneumoniae and acinetobacter bauman were detected in both groups during the treatment.There was no significant difference of positive rate between two groups (P >0.05).Conclusion Combination therapy of bioactive glass and bath treatment can effectively promote healing of burn wound.%目的：探讨生物活性玻璃结合浸浴治疗烧伤残余创面的疗效。方法将60例烧伤残余创面患者随机分为试验组和对照组，每组30例。试验组采用浸浴治疗结合创面外用生物活性玻璃，对照组采用浸浴治疗结合外用碘伏纱布覆盖。观察2组患者创面在用药7、14、21 d 的愈合程度及肉芽生长情况。记录2组患者创面在用药7、14、21 d 的细菌检出情况及不良反应。结果试验组创面用药14 d愈合7例，21 d愈合8例；对照组14 d愈合1例，21 d愈合3例。试验组总有效率为93．3％，显著高于对照组的56．7％（P ＜0．01）。2组患者在用药7、14、21 d 均检到细菌，包括金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌以及鲍曼不动杆菌。2组细菌检出阳性率无显著差异（P ＞0．05）。结论生物活性玻璃结合浸浴治疗能安全有效地促进烧伤残余创面愈合。