腹腔镜与开腹直肠癌扩大根治术对老年患者细胞免疫功能的影响

摘要

目的 探讨腹腔镜与开腹直肠癌扩大根治术对老年患者细胞免疫功能的影响.方法 选取60例老年结肠、直肠癌患者,按抽签方式分为对照组和研究组各30例.对照组采用开腹直肠癌扩大根治术治疗,研究组采用腹腔镜直肠癌扩大根治术治疗.分别于术前1d及术后1、3、5d抽取所有患者清晨空腹静脉血,测定T淋巴细胞亚群(CD3+、CD4+、CD8+)水平并进行比较分析.结果 与本组术前1d相比,对照组术后1、3、5d和研究组术后1、3d的CD3+、CD4+、CD8+水平均显著下降(P＜0.05);术后1、3、5d,研究组CD3+、CD4+、CD8+水平较对照组显著更高(P＜0.05).结论 腹腔镜与开腹直肠癌扩大根治术对老年患者细胞免疫功能均有一定影响,但腹腔镜直肠癌扩大根治术对患者细胞免疫功能的影响明显更小,有利于保护患者细胞免疫功能.%Objective To investigate the effect of laparoscopic and open extended radical resection of rectal carcinoma on cellular immune function of elderly patients.Methods A total of 60 elderly patients with colorectal cancer were enrolled and divided into two groups according to therapeutic methods.The control group was treated with open extended radical resection of rectal carcinoma,and the study group was treated with laparoscopic extended radical resection of rectal carcinoma.The fasting venous blood of all patients 1 day before operation and 1,3 and 5 days after operation were measured,and the levels of T lymphocyte subsets (CD3 +,CD4 +,CD8 +) were measured and compared.Results Compared with the levels of indexes 1 day before operation,CD3 +,CD4 +,CD8 + in the control group 1,3 and 5 days after operation and 1,3 days after operation in study group significantly decreased (P ＜ 0.05).The 1,3 and 5 days after operation,the CD3 +,CD4 + and CD8 + in study group were significantly higher than the control group (P ＜ 0.05).Conclusion Laparoscopic and open extended radical resection of rectal carcinoma have a certain impact on cellular immune function,but effect of laparoscopic extended radical resection of rectal carcinoma is relatively less,which is conducive to the orotection of cellular immune function.