2型糖尿病患者踝臂指数与尿微量白蛋白/肌酐比值的相关性

摘要

目的 探讨2型糖尿病(T2DM)患者踝臂指数(ABI)与尿微量白蛋白/肌酐比值(UACR)的相关性.方法 将141例2型糖尿病患者分为正常ABI组(0.9≤ABI＜ 1.4,99例)和异常ABI组(ABI＜ 0.9,42例),分析两组的性别、年龄、病程、体重指数(BMI)、UACR、尿素氮(BUN)、总胆固醇/三酰甘油(TC/TG)、糖化血红蛋白(HbA1c)等指标.结果 与正常ABI组比较,异常ABI组患者的病程、BUN、UACR、HbA1c水平升高,两组比较差异有统计学意义(P＜0.05).ABI与病程、UACR、BUN呈负相关(相关系数分别为-0.634、-0.757和-0.578,P均＜0.01).结论 ABI与UACR呈负相关.异常ABI具有重要预警意义,能较早期地反映糖尿病患者肾功能的受损,对于筛查早期糖尿病肾病有重要临床意义.%Objective To investigate the association between ankle-brachial index (ABI) and urinary albumin/creatinine ratio(UACR) in patients with type 2 diabetes mellitus(T2DM). Methods 141 patients with type 2 diabetes mellitus were divided into the abnormal ABI group(n =42, ABI <0. 9)and the normal ABI group ( n = 99,0. 9 ≤ ABI < 1. 4). The gender, age, clinical course, BMI, UACR, BUN, TC/TG,HbAlc in two groups were measured. Results The differences of clinical course, BUN, UACR, HbAlc between the two groups was statistically significant(P < 0. 05 ). ABI and clinical course, UACR, BUN of correlation coefficient were -0.634, -0.757, -0. 578,and the corresponding P value was less than 0. 01 ,with statistical significance. Conclusions The statistical analysis showed that UACR produced a negative influence on ABI. The results of abnormal ABI has an important warning. It can diagnose early diabetic kidney injury and has a very significant diagnostic for early diabetic nephropathy.