Objective To observe the clinical efficacy of butylphthalide in treating mild cognitiveimpairment(MCI).Methods 90 patients were divided into the treatment group(treated with conventionaldrugs and butylphthalide)and the control group(treated with conventional drugs).Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),Chinese Stroke Scale(CSS)and Barthel Index(BI)were adopted to evaluate the cognitive and neurological status of patients before the treatment and3 months later.Results Cure rates were 84.0% in the treatment group and 57.5% in the control group.Effective rates were 98.0% in the treatment group and 82.5% in the control group.Both the differenceswere statistically significant(P <0.05).Compared with the control group,MMSE score,CSS score and BIscore for the treatment group increased significantly(P <0.01),MoCA score increased significantly(P <0.05).Conclusion Butylphthalide is effective and safe for the treatment of mild cognitive impairmentafter cerebral infarction.%目的:观察丁基苯酞在脑梗死后轻度认知障碍(MCI)患者中的临床疗效。方法将90例患者随机分为治疗组和对照组,治疗组给予常规药物加丁基苯酞,对照组仅用常规药物。采用简易智能状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)、中国卒中量表(CSS)及巴氏指数量表(BI)对两组患者治疗前、治疗3个月后认知和神经功能状况进行评估。结果治疗组基本治愈率为84.0%,对照组为57.5%;治疗组总有效率为98.0%,对照组为82.5%,差异均有统计学意义(P <0.05)。与对照组比较,治疗组 MMSE、CSS 及 BI 量表评分明显增加(P <0.01);MoCA 评分增加,差异有统计学意义(P <0.05)。结论丁基苯酞治疗脑梗死后轻度认知障碍较为有效安全。
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