人类白细胞抗原(HLA) -Ⅰ类抗原除了主要以跨膜蛋白形式存在于人体有核细胞膜之外,还有少量以可溶性状态存在于人类血液、尿液、淋巴液、乳汁等体液中,被称为可溶性人类白细胞抗原( sHLA).sHLA-Ⅰ类抗原在肝炎、肝胆胰系统肿瘤及移植的患者血清中都有明显的变化.本文就sHLA-Ⅰ类抗原的结构及在临床疾病中的意义作一综述.%In addition to the main form of human HLA - I , existing as a transmembrane protein in the nuclear membranes of human cells, there is a small amount of soluble form (Shla - I ) found in many body fluids, including blood, urine, lymph, and breast milk,et al. Significant changes of Shla - I in serum are observed in individuals with hepatitis, hepatobiliary and pancreatic tumors, organ transplantation. In this paper, the structure of Shla - I and the significance of the protein in diseases are discussed.
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