丙型肝炎病毒抗体依赖性增强作用的研究现状及意义

摘要

抗体协助病毒进入靶细胞,提高感染率,这一现象称为抗体依赖性增强作用(ADF).ADE一方面保护免疫的诱导作用,另一方面增强敏感性的诱导作用,它们之间存在微妙的平衡关系.人们发现在多种病毒感染中广泛存在ADE效应,且常规疫苗预防及治疗此类病毒感染难以奏效.因此,近年来ADE越来越受到人们的重视.本文着重阐述ADE效应在丙型肝炎病毒(HCV)中的作用机制,旨为HCV发病机理及慢性丙型肝炎治疗、HCV疫苗研发提供新思路.%Antibody- dependent enhancement(ADE) is a phenomenon in the process of virus infection which refers to the virus -specific antibodies which can help or facilitate virus to enter the target cells. These antibodies have double effects, which are balanced between protection effects or enhancement effects of infection according to different antibody concentration. ADE is observed in many virus infection processes, moreover, the conventional vaccine usually has no effect to prevent or treat them. In this review, we discuss the mechanism of ADE in HCV infection, aiming to provide some new thoughts for HCV pathogenesis study, therapy and vaccine research.