乙型肝炎病毒核心相关抗原的监测及临床意义

摘要

Antiviral nucleot( s) ide analogs are the common therapy for patients with chronic hepatitis B ( CHB) infection. HBV DNA in peripheral blood is a sufficient and convenient indicator of treatment response and resistance; however, intrahepatic HBV DNA and covalently closed circular (ccc) DNA are superior indicators of treatment failure at earlier stages. Unfortunately, monitoring of intrahepatic nucleic acids, including HBV DNA, cccDNA and RNA, is complicated and expensive. Since serum levels of hepatitis B virus core -related antigen ( HBcrAg) correlate well with intrahepatic levels of HBV cccDNA it may represent an accurate and convenient indicator of treatment response and resistance in CHB patients. In this review, we discuss the recent research efforts to develop strategies for HBcrAg monitoring and to define the underlying mechanisms of this clinical indicator system. Besides its promising clinical value, large - scale dynamic measures of HBcrAg in CHB patients may provide useful insights into the risk and causative factors of resistance to antiviral nucleot(s) analoge therapy.%监测乙型肝炎病毒核心相关抗原(HBcrAg),能有效预测核苷(酸)类药物抗病毒治疗后产生的病毒学反弹及耐药风险,具有重要的临床实用价值.