细针型共聚焦激光显微内镜在胰腺囊性病变诊断中的应用

摘要

胰腺囊性病变（PCLs）的病理类型多样，生物学行为差异极大，其预后各不相同。目前的诊断主要依据患者的病史、临床表现、影像学检查、血清学检查以及细针穿刺活组织检查、囊液细胞学检查综合分析。细针型共聚焦激光显微内镜是一种新型显微内镜，其可与19 G 穿刺针匹配应用，在超声内镜引导下对 PCLs 在体实时显示病变组织细胞、亚细胞结构，进而实现对 PCLs 的准确诊断。对细针型共聚焦激光显微内镜在诊断 PCLs 中的应用进行了概述。%Pancreatic cystic lesions (PCLs)have various pathological types,extremely different biological behaviors,and different progno-sis.Current diagnosis of PCLs mainly depends on a comprehensive analysis of the patient's medical history,clinical manifestations,imaging examinations,serological examinations,fine needle aspiration biopsy,and cytological examination of cyst fluid.Needle -based confocal la-ser endomicroscopy (nCLE)is a novel method of microscopic endoscopy and is compatible with 19 -gauge puncture needle.Under the guid-ance of endoscopic ultrasound,nCLE can achieve real -time in vivo imaging of the cellular and subcellular structures of diseased tissues and thus helps with the accurate diagnosis of PCLs.This article reviews the application of nCLE in the diagnosis of PCLs.