Objective To study the clinical efficacy of tiopronin and metformin in treatment of NAFLD. Methods Eighty cases of NAFLD were randomly divided into two groups, trial group and control group, each with 40 cases. Patients in trial group were treated with tiopronin and metformin, and patients in control group were only treated with tiopronin, the therapeutic course in both groups was 6 months, and there was no any drug against hepatitis or hyperlipidemia. Clinical manifestations, liver function test and blood level of lipids were observed during the therapeutic course of 6 months, and their clinical efficacy had been evaluated. Results Liver function, blood lipids and insulin resistance were obviously improved after treatment, there was significant difference( P <0.05 )between these 2 groups. The total effective rate of trial group was 90.0% , and that of control group was 67. 5% , the difference between these two groups was significant( P <0.05 ). Conclusion Tiopronin combined with metformin can obviously raise the clinical efficacy in treatment of NAFLD, and this combined therapy is much safer.%目的 探讨硫普罗宁联合二甲双胍治疗非酒精性脂肪性肝病的临床疗效.方法 选择80例非酒精性脂肪性肝病患者随机分为两组,治疗组和对照组各40例;治疗组采用硫普罗宁联合二甲双胍治疗,对照组单用硫普罗宁治疗,两组疗程均为6个月,治疗期间不用其他保肝降酶和降血脂类药物;6个月后观察两组患者治疗前后症状、体征变化及肝功能、血酯等指标水平变化,评定临床疗效.结果 治疗组肝功能、血脂各项指标及胰岛素抵抗显著改善,与对照组比较有显著性差异(P<0.05);治疗组总有效率90.0%,对照组总有效率67.5%,两组比较有显著性差异(P<0.05).结论 硫普罗宁联合二甲双胍治疗非酒精性脂肪性肝病能明显提高临床疗效,且用药安全性高.
展开▼
