Objective To study the clinical and pathological data of female patients with breast cancer based on different age ranges. Methods Patients with breast cancer were collected and divided into ≤40 years old group ,41~54 years old group and ≥55 years old group according to different age ranges. Then TNM staging was observed and ER, PR, Her2, BHCA and Ras expression in breast cancer had been detected by immunohistochemical method. Results Cases with TNM II and positive ER, PR, BRCA expression in ≤40 years old patients group were significantly less than those of 41 ~ 54 years old group and ≥55 years old group; cases with TNM Ⅲ, Ⅳ and positive Her2, Ras expression were significantly greater than those of 41~54 years old group and ≥55 years old group. Conclusion Patients with age range ≤40 years old have higher degree of malignancy for its low TNM stage with high expression of proto - oncogene and low expression of tumor suppressor gene.%目的 研究不同年龄段乳腺癌患者的临床病理特征.方法 选择就诊的乳腺癌患者,根据年龄分为≤40岁组、41～54岁组、≥55岁组,观察TNM分期,并采用免疫组织化学的方法检测乳腺癌组织中雌受体激素(ER)、孕受体激素(PR)、乳腺癌1号基因(BRCA)、表皮生长因子受体-2(Her2)、Ras基因(ras gens)表达情况.结果 ≤40岁组患者TNMⅠ期、Ⅱ期例数以及ER、PR、BRCA阳性例数均明显少于41～54岁组、≥55岁组;Ⅲ期、Ⅳ期例数以及Her2、Ras阳性例数均明显多于41～54岁组、≥55岁组.结论 ≤40岁的年轻乳腺癌患者TNM分期差、原癌基因表达水平高、抑癌基因表达水较低,恶性程度较高.
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