PBMCs 生成 IL-10、IL-12的水平与晚期 NSCLC 患者感染的相关性研究

摘要

Objective To assess if the variation of IL - 10 and IL - 12 generated by peripheral blood mononuclear cells(PBMCs)is a predictive factor for the severe infection in advanced non - small cell lung cancer(NSCLC)patients. Methods Forty - five cases of advanced NSCLC were included in the study. The patients were divided into initial infection group(n = 15),one month after recovery from infection group (n = 15)and non - infection group(n = 15). Fifteen healthy subjects were in control group. Peripheral blood with heparin anticoagulant was ob-tained from the four groups,and IL - 10 and IL - 12 production in the culture supernatant of PBMCs was determined by ELISA. Analysis of vari-ance was used to analyze the difference among groups and P 0. 05). IL - 12 levels in the initial infection group,recovery from infection group and non- infection group were higher compared to the healthy control group( P 0.05）。IL -12的表达水平在 IIG、RIG 和 NIG 组均高于 HC 组，差异有统计学意义（ P <0.01）；虽然 RIG 组的 IL -12水平低于 IIG 组，但仍高于 HC 组，差异具有统计学意义（ P =0.01）。结论 PBMCs 生成的 IL -12水平不仅是肿瘤负荷存在的标志，也是一个 NSCLC 患者合并严重感染或感染后恢复的预测因素。