目的：探讨厄贝沙坦与钙离子拮抗剂联合用于老年2型糖尿病肾病合并高血压的治疗效果。方法将2012年10月至2013年10月确诊并进行治疗的2型糖尿病肾病合并高血压的136例老年患者按照就诊顺序随机分为两组，每组各68例。对照组单纯采用厄贝沙坦治疗，观察组在对照组的基础上加用硝苯地平控释片进行治疗，连续治疗8周后，比较两组患者治疗前后血压、血糖水平及肾功能的改变情况。结果观察组总有效率为92.65%，显著高于对照组的76.47%（ P <0.05）；治疗后两组患者收缩压（SVP）、舒张压（DPV）及糖化血红蛋白（HbAlC）水平均较治疗前明显下降（ P <0.05），但观察组的下降幅度明显大于对照组（ P <0.05）；观察组治疗后24 h 尿蛋白（24 h Upro）、血肌酐（SCr）和血尿素氮（VUN）水平均较治疗前和对照组显著降低（ P <0.05）。结论厄贝沙坦与钙离子拮抗剂联合应用老年2型糖尿病肾病合并高血压，可有效地调节患者血压、血糖水平，改善患者肾功能，值得临床推广和应用。%Objective To investigate the clinical effect of irbesartan combined with calcium antagonists in treatment of senile type 2 dia-betic nephropathy merger hypertension. Methods 136 cases of elderly patients with type 2 diabetic nephropathy merger hypertension from October 2012 to October 2013 were diagnosed and treated. All these patients were randomly divided into two groups of 68 cases in each group. The control group was only given irbesartan for treatment while the observation group was given nifedipine controlled release tablets on basis of that,with con-tinuous treatment for 8 weeks. The changes of blood pressure,blood glucose levels and renal function before and after treatment were compared. Results The total effective rate of the observation group was 92. 65% ,significantly higher than that in control group 76. 47%( P < 0. 05). The SVP,DPV and HbAlc levels of the two groups after treatment were significantly decreased than before treatment( P < 0. 05),but that in the ob-servation group decreased significantly than that in the control group( P < 0. 05). The 24 h Upro,SCr and VUN levels of the observation group after treatment decreased significantly when compared with before treatment and control group( P < 0. 05). Conclusion Irbesartan combined with calcium antagonists has a significantly curative effect in treatment of elderly type 2 diabetic nephropathy complicated with hypertension,which can effectively regulate blood pressure,blood glucose of patients,improve the renal function of patients,that is worthy of promotion and application.
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