鞘内注射药物联合腰大池置管持续引流术对颅脑术后颅内感染治疗效果评价

摘要

Objective To evaluate the treatment effects of intrathecal drug combined with continuous external lumbar drainage for in-tracranial infection after craniocerebral operation,so as to supply scientific reference of efficient treatment. Methods 150 cases of patients with intracranial infection after craniocerebral operation admitted from 2009 December to 2014 December in our hospital were considered as the research objects,and their clinical data were analyzed retrospectively. There were 72 patients treated with continuous external lumbar drainage in the control group,while 78 patients in the experimental group were used with intrathecal drug and continuous external lumbar drainage for treatment. The treatment effect,white blood cells,protein,glucose,body temperature,intracranial pressure were observed and compared between these two groups. Results Before the treatment,there were no difference between these two groups about white blood cell,proteins,glucose,temperature and intracranial pressure( P ﹥0. 05). After the treatment,the index stated above in the experimental were superior than that of the control group [ white blood cell:(229. 9 ± 13. 3)× 106/L vs.(232. 1 ± 10. 6)× 106/L;proteins:(1. 8 ± 0. 4)g/L vs.(1. 9 ± 0. 3)g/L;glucose:(1. 1 ± 0.5)mM vs.(1.0 ±0.2)mM;temperature:(39.3 ±2.9)℃vs.(38.9 ±1.5)℃;intracranial pressure:(253.8 ±10.9)mmHg vs.(254.1 ± 12. 1)mmHg]. What is more,the treatment effects were better in the experimental group than that of control group(92. 31% vs. 73. 61%),and there were significant differences analyzed by statistical methods between the groups stated above( P ﹤0. 05). Conclusion The treatment effect to combine intracranial infection with continuous external lumbar drainage for intracranial infection after craniocerebral operation. Therefore,this method is worth spreading and using in clinic.%目的探讨鞘内注射药物联合腰大池置管持续引流术对颅脑术后颅内感染的治疗效果。方法随机选取2009年12月至2014年12月期间收治的150例颅脑术后颅内感染患者作为研究对象，并回顾性分析其病历资料，其中单纯采用腰大池置管持续引流术治疗患者72例（对照组），而鞘内注射药物联合腰大池置管持续引流术治疗患者78例（实验组）。观察两组患者的治疗效果，并对白细胞、蛋白质、葡萄糖、体温、颅内压结果进行比较。结果治疗前，两组患者在白细胞、蛋白质、葡萄糖、体温、颅内压等方面无显著性差异（ P ﹥0.05），治疗后，实验组患者上述指标值均优于对照组[白细胞：（229.9±13.3）×106/L vs.（232.1±10.6）×106/L；蛋白质：（1.8±0.4）g/L vs.（1.9±0.3）g/L；葡萄糖：（1.1±0.5）mM vs.（1.0±0.2）mM；体温：（39.3±2.9）益vs.（38.9±1.5）益；颅内压：（253.8±10.9）mmHg vs.（254.1±12.1）mmHg]；实验组患者治疗总有效率明显高于对照组（92.31% vs.73.61%），差异均具有统计学意义（ P﹤0.05）。结论与单纯腰大池置管引流术比较，鞘内注射药物联合腰大池置管引流术对颅脑术后颅内感染具有较好的治疗效果，值得临床推广应用。