目的：探析应用卡培他滨不同方案治疗晚期胃癌与术后复发转移胃癌患者的临床效果。方法采用随机数字表法将120例晚期胃癌与术后复发转移胃癌患者分为 A、B、C 三组，每组40例。A 组患者给予奥沙利铂与卡培他滨联合治疗，B 组患者给予多烯紫杉醇联合卡培他滨治疗，C 组患者给予卡培他滨单独治疗。比较不同方案治疗后的临床效果、肿瘤标志物水平、患者生存质量评分和安全性等情况。结果经过不同方案治疗后，A 组患者的总有效率（80.00%）明显高于 B 组患者总有效率（60.00%）、C 组患者总有效率（50.00%），差异有统计学意义（ P 0.05）；A 组患者的癌胚抗原（CEA）、癌抗原724（CA724）、CA242和 CA199指标水平均明显低于 B、C 组患者，差异有统计学意义（ P 0.05）；治疗后，A 与 B、C 两组相比在生理、社会和家庭、情感及功能状况等生存质量评分方面更有优势，差异有统计学意义（ P 0.05）。结论晚期胃癌与术后复发转移胃癌患者应用奥沙利铂与卡培他滨联合治疗后，临床效果明显优于多烯紫杉醇联合卡培他滨治疗及给予卡培他滨单独治疗，治疗后肿瘤标志物指标得以维持在一定良好水平，预后的生存质量较高。%Objective To study the clinical effect of capecitabine on the patients of advanced gastric cancer and postoperative recurrence metastasis gastric cancer. Methods By random number table method,120 cases of gastric cancer patients were divided into A,B,C groups. The patients in group A are treated with oxaliplatin combined with capecitabine therapy,and the patients in group B were treated with docetaxel com-bined with capecitabine treatment,the patients in group C are given capecitabine treatment alone,and the clinical effect was compared. Results After different treatment,The total efficiency in patients of group A(80. 00% )was significantly higher than group B patients(60. 00% ),group C(50. 00% ),the difference was statistically significant( P 0. 05). The carcinoembryonic antigen(CEA),cancer antigen 724( CA724),CA242 and CA199 indicators in group A were significantly lower than those of group B,group C patients,the difference was statistically significant( P 0. 05). After treatment,patients in A group have an advantage compared with B and C group,the difference was statistically signifi-cant( P 0. 05). Conclusion Advanced gastric cancer,postopera-tive recurrence and metastasis in patients with gastric cancer treated with oxaliplatin and capecitabine combination therapy,clinical effect is obvi-ously better than docetaxel combined card capecitabine treatment and capecitabine treatment alone. After treatment,tumor markerss can be main-tained at a certain level and the prognosis of survival quality higher.
展开▼
