妊娠期糖尿病并发子痫前期患者血清Lipocalin-2、sFlt-1、PIGF水平及临床意义

摘要

Objective To detect clinical significance of serum Lipocalin-2, sFlt-1 and PIGF levels in patients with gestational diabetes mellitus complicated with preeclampsia.Methods A total of 212 pregnant women were selected from March 2013 to June 2015 as the study subjects.They were divided into GDM-PE group (n=45), GDM group (n=55), PE group (n=52), and normal pregnant women group (n=60).Then the expression of Lipocalin-2, sFlt-1 and PIGF were detected by ELISA.Results There were no significant differences in age, gestational age and pre-pregnancy BMI among the four groups (P>0.05).GDM-PE group had higher BMI, systolic blood pressure and diastolic blood pressure than GDM group and Control group (P0.05).GDM-PE组孕期BMI、收缩压、舒张压等各项指标均大于GDM组和对照组(P<0.05).PE组和GDM-PE组孕期BMI、收缩压、舒张压等各项指标均大于GDM组和对照组(P<0.05).ELISA检测结果显示:和对照组相比,Lipocalin-2在GDM、PE及GDM-PE组表达水平均升高(P<0.05),GDM-PE组Lipocalin-2表达高于GDM组和PE组(P<0.05);sFlt-1表达在GDM、PE及GDM-PE组均高于对照组(P<0.05),在PE及GDM-PE组均高于GDM组(P<0.05);PIGF表达在GDM、PE及GDM-PE组均低于对照组(P<0.05).结论 血清Lipocalin-2和sFlt-1水平在GDM-PE患者中会明显升高,而PIGF水平则会明显降低,其原因可能与胰岛素抵抗和内皮细胞损伤有关.三个指标联合应用于早期预测GDM-PE疾病具有一定的临床意义.