视神经脊髓炎患者血清NMO-IgG、hs-CRP及触珠蛋白的水平变化及其意义

摘要

目的 探讨视神经脊髓炎(NMO)患者血清水通道蛋白4特异度结合的自身抗体-抗水通道蛋白4抗体(NMO-IgG)、超敏C反应蛋白(hs-CRP)、触珠蛋白的水平变化及其意义.方法 选取2011年1月至2016年12月确诊的NMO患者54例(A组)、长节段横惯性脊髓炎患者31例(B组)、多发性硬化患者31例(C组)进行回顾性分析,检测三组患者血清NMO-IgG、hs-CRP、触珠蛋白水平并进行比较分析.结果 急性期,血清NMO-IgG水平比较,A组高于B组、C组(P0.05);NMO患者急性期血清NMO-IgG、hs-CRP、触珠蛋白水平、EDSS评分均显著高于缓解期,差异具有统计学意义(P0.05).结论 NMO患者血清NMO-IgG、hs-CRP、触珠蛋白的水平变化与患者病情程度具有一定的关系,检测上述指标对于指导临床治疗具有一定的价值.%Objective To study neuromyelitis optica (NMO) water channel protein 4 in serum of patients with specific antibodies of anti aquaporin 4 antibody (NMO-IgG), high sensitive C reactive protein (hs-CRP), changes in the levels of keratin protein and its significance.Methods From January 2011 to December 2016, 54 NMO patients (A group), 31 patients with long segment inertia transverse myelitis (group B), 31 patients with multiple sclerosis (group C) were retrospectively analyzed.The serum NMO-IgG, hs-CRP, keratin protein level were detected and compared.Results In acute phase, serum NMO-IgG levels in group A were higher than those in group B and group C (P0.05).The serum NMO-IgG, hs-CRP, haptoglobin, EDSS scores in group A were significantly higher than those in remission, the difference was statistically significant (P0.05).Conclusion The levels of serum NMO-IgG, hs-CRP and keratin in patients with NMO have a certain relationship with the severity of the disease, which has value in guiding clinical treatment.