针药结合调节抑郁症患者 Th1／Th2平衡的研究

摘要

Objective:To evaluate the clinical efficacy on depression by acupuncture combined with SSRI anti-depressant , and to discuss its functional mechanism on Th 1/Th2 balance .Methods:122 depressive patients were randomly divided into two groups , acupuncture with antidepressant group and control group .The control group(61 cases) was treated with Fluoxetine Hydrochloride tablets , whereas the acupuncture with antidepres-sant group was treated with acupuncture combined with Fluoxetine Hydrochloride tablets .Four weeks was as a course .HAMD and SDS were used as clinical evaluation scale .The serum secretions of IFN -γand IL-4 were detected by ELISA method .Results:After one course treatment , there was a significant difference between two groups on HAMD and SDS points ( P<0 .05 ) ,and the therapeutic effect was better in the acupuncture with antidepressant group than that in the control group (P<0.05).The secretions of IFN-γin both groups were remarkably lower than pre -treatment ( P<0 .05 ) .The secretions of IL -4 in both groups were remarkably higher than pre-treatment (P<0.05).The difference between two groups on IFN -γand IL-4 after treat-ment was significant ( P <0.05).Conclusion:Acupuncture combined with SSRI antidepressant has a good effect in the clinic , and its functional mechanism may be related to adjusting the balance of Th 1/Th2.%目的：评价针药结合治疗抑郁症的临床疗效，探讨其调节Th1/Th2平衡的作用机制。方法：122例抑郁症患者随机分为针药组和对照组各61例。对照组口服氟西汀，针药组在口服氟西汀的基础上配合针刺治疗。4周为一疗程。采用HAMD抑郁量表、SDS抑郁自评量表评价疗效；ELISA法检测两组患者治疗前后血清IFN-γ和IL-4的分泌水平。结果：治疗后两组患者HAMD和SDS量表评分均显著下降（P＜0．05），针药组疗效优于对照组（P＜0．05）；治疗后两组患者IFN-γ水平均显著下降，IL-4水平均显著上升（P＜0．05），针药组与对照组相比有显著性差异（P＜0．05）。结论：在应用抗抑郁药的基础上配合针刺疗效好，其作用机制可能与调节Th1/Th2平衡有关。