Objective Investigates expression of PTEN(Phosphatase and tensin homology deleted on chromosome ten , PTEN) in bladder transitional cell carcinoma (BTCC) and its clinical significance.Methods Fifty-one cases of bladder transitional carcino -ma, forty-two cases of Cystitis Glandularis(CG) and ten cases of normal bladder tissue 10 cases of normal bladder tissue were collect -ed.All samples were derived from cystoscopic biopsy and were subjected to histopathological examination to confirm the diagnosis .Im-munohistochemistry S-P methods is used to demonstrate the expression of PTEN .Results The positive rate of PTEN expression in BTCC, CG and normal bladder tissue are 58.8%, 81% 100%,and there is statistic significance ( P <0.01) among three groups.51 cases of BTCC are divided into group G Ⅰ ,GⅡ ,GⅢ and Tis -T1 ,T2-T4 ,and there is statistic significance among group G Ⅰ and GⅡ, GⅢ ( P <0.01),between group Tis -T1 and T2-T4 ( P <0.05).Conclusions The reduced expression or loss of PETN might play an important role in carcinogenesis and progression of bladder cancer .The positive rate of PTEN expression was negatively correlated to the clinical and grade staging of tumor .%目的：分析 PTEN 蛋白在膀胱移行细胞癌（BTCC）、腺性膀胱炎及正常膀胱黏膜组织中的表达特点及临床意义。方法收集温州医科大学附属第一医院病理科膀胱黏膜组织病理标本，其中膀胱癌51例，腺性膀胱炎42例；正常膀胱黏膜组织10例。采用 S－P 免疫组化法，检测 PTEN 在相应的膀胱黏膜组织石蜡切片中的表达特点。结果PTEN 蛋白在膀胱移行细胞癌及腺性膀胱炎组织表达的阳性率分别是58．82％、80．95％，而10例正常膀胱黏膜组织 PTEN 全呈阳性表达，三组比较总体差异有统计学意义（ P ＜0．01）；膀胱移行细胞癌组与腺性膀胱炎组及正常膀胱黏膜组比较差异均有统计学意义（ P ＜0．05），而腺性膀胱炎组与正常膀胱黏膜组间差异无统计学意义（ P ＞0．05）。在51例膀胱移行细胞癌病理分组中，PTEN 蛋白的阳性表达 GⅠ组与 GⅡ、GⅢ组比较总体差异有统计学意义（ P ＜0．01），GⅠ组与 GⅡ组及 GⅢ组比较差异有统计学意义（ P ＜0．01），而 GⅡ组与 GⅢ组比较差异无统计学意义（ P ＞0．05）；临床分期中，Tis－T1组与 T2－T4组比较差异有统计学意义（ P ＜0．05）。结论PTEN 蛋白在膀胱移行细胞癌中的阳性表达率较腺性膀胱炎及正常膀胱黏膜组织中低，其阳性表达率随着肿瘤恶性程度、病理分级的增加而降低，在一定程度上有助于膀胱癌与正常膀胱黏膜组织及恶性程度、病理分级的区别。
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